Latino children are at greater risk of developing certain cancers, and their short and long-term outcomes are often worse than other children with cancer. Approximately 1 in 15 children receiving cancer treatment in low- and middle-income countries die from treatment-related complications. Although treatment-related mortality has decreased in upper–middle-income countries over time, it remains unchanged in low- and middle-income countries. There is an urgent need for targeted supportive care interventions to reduce global disparities in childhood cancer survival. The FDA has issued a complete response letter to a resubmitted biologics license application (BLA) for remestemcel-L as a treatment for pediatric patients with steroid refractory acute graft-versus-host-disease (SR-aGVHD). High gut microbiota diversity before allogeneic hematopoietic stem cell transplantation (allo-HSCT) was associated with significantly better survival outcomes in children. Researchers have found a potential drug candidate that improved outcomes for patients with a type of childhood brain tumor for which there are no effective treatments. The compound, called ONC201, nearly doubled survival for patients with diffuse midline glioma (DMG) or diffuse intrinsic pontine glioma (DIPG), compared to previous patients. Starting a new school year is often stressful for many students. For those living with a disability such as hearing loss, this anxiety can be magnified. Dr. Alison Freeman offers a wealth of expert advice on supporting kids of all ages as they go back to school for another year. “We are in an era of radiation omission or de-escalation,” said Corey Speers, vice chair of radiation oncology at the University Hospitals Seidman Cancer Center and Case Western Reserve University. “Radiation is perhaps one of the most precise and most effective cancer therapies we have, so it will always play an important role in cancer management, but there are situations now on an individual patient basis where radiation may not be needed.” Scientists have shown that immunotherapy after stem cell transplantation effectively combats certain nerve tumors in children. Crucially, stem cells from a parent provide children with a new immune system that responds much better to immunotherapies.