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Assorted News from the Last Week: The Global Initiative for Childhood Cancer aims for a two-thirds remission rate by 2030, saving the lives of approximately one million children worldwide. U.S. Food and Drug Administration approves Immix Biopharma pare pediatric disease designation for IMX-110 as a treatment for life-threatening pediatric cancer in children Obesity linked to subsequent neoplasms in childhood cancer survivors. Virginia Tech researchers are developing more precise treatments for pediatric brain cancer using a new class of therapies that target cancer cells while sparing healthy tissue. The Nepal Childhood Cancer Alliance (NCCA) marked International Cancer Survivor Day by launching [...] Read more

Assorted News from the Last Week: Children and young people are waiting longer than necessary for cancer diagnosis, according to new research. Disruptions to school, work and personal milestones are only some of the disruptions that adolescent and young adult (AYA) patients with lymphoma uniquely face following their diagnosis, creating a need for individualized care which would take emotional and psychosocial needs into consideration. Pediatric cancer patients and their caregivers largely prefer to access test results immediately through the patient portal rather than wait to hear about results from oncologists. Two Wilms tumor articles: It remains unclear why some paediatric [...] Read more

Assorted News from the Last Week: The National Cancer Institute reports that about 85 percent of children diagnosed with cancer are alive five years after diagnosis. That news is encouraging, but long-term survivor care brings its own challenges. Research on children diagnosed with acute lymphoblastic leukemia (ALL) shows that the longer a patient’s body mass index (BMI) falls within the overweight/obese category during treatment, the greater the risk of relapse and the lower the chance of survival. Influence of genetic biomarkers on cardiac diseases in childhood cancer survivors: a systematic review The FDA has granted regenerative medicine advance therapy (RMAT) [...] Read more

Assorted News from the Last Week: In CAC2’s May webinar, “Fertility Hope for Childhood Cancer Survivors” our speakers explored fertility preservation and future family building options for childhood cancer patients and survivors. Childhood cancer survivors at increased risk of  chronic kidney disease and hypertension, this matched cohort study followed patients for up to 27 years. Study reveals targetable mechanism behind high-risk predisposition gene in pediatric medulloblastoma. The FDA approved the first oral therapy for rare adrenal gland tumors and includes children 12 years and older. Epigenetics predicts the aggressiveness of Burkitt lymphoma, a common pediatric tumor in developing countries. As [...] Read more

Assorted News from the Last Week: If you weren’t able to join us for the “Know Before You Go” drop-in session for CAC2 Members, it isn’t too late to catch up on all the action. The National Comprehensive Cancer Network (NCCN) has updated its guidelines to include the category 2A recommendation of a naxitamab-gqgk (Danyelza)-based regimen for adult and pediatric patients with high-risk neuroblastoma. A new government study provides the most complete picture yet of early-onset cancers, finding that the largest increases are in breast, colorectal, kidney and uterine cancers. Scientists from the National Cancer Institute looked at data that included [...] Read more

Assorted News from the Last Week: In CAC2’s April pop-up webinar, “Patient Advocacy, Non-Profit Foundations, and the Changing Landscape of Pediatric Cancer Funding,” our special guest, Dr. Kimryn Rathmell, shared compelling insights on the evolving pediatric cancer landscape and the role of advocates. A highly sensitive bone marrow test could double survival rates for some groups of younger adults with Acute Myeloid Leukaemia (AML) by helping doctors identify if they might relapse up to three months earlier. Experts call for research, improved care for Nigerian children with cancer. ‘Nerve-wracking:' Childhood cancer clinical trials endangered by possible budget slashes. Black and [...] Read more

Assorted News from the Last Week: Parents of kids with cancer fear GOP budget cuts could slash Medicaid What I wish I had known: A pediatric oncologist's transition to survivorship care The Food and Drug Administration (FDA) has granted breakthrough therapy designation to treatment with an investigational B7-H3 targeting autologous CAR-T cell therapy for pediatric patients with diffuse intrinsic pontine glioma. Researchers trained and validated a deep learning model that can detect subtle changes across post-treatment brain scans and forecast pediatric glioma recurrence with up to 89 percent accuracy. Living in a persistent-poverty neighborhood was associated with a higher risk [...] Read more

Assorted News from the Last Week: A study explores the effects of identifying pediatric cancer survivors at risk for complications, developing targeted interventions, determining where and how to provide life-long risk-based care, and whether providing risk-based surveillance will mitigate the burden of morbidity and mortality among childhood cancer survivors. A proposed cancer survivorship model that involves interdisciplinary coordination and the use of digital tools has the potential to “move the outcomes needle.” Only half of adolescents and young adults with cancer get fertility counseling before treatment. Psychological empowerment interventions that are technology-based significantly improve the psychological well-being of parents of [...] Read more